Research Interest: Cancer Metabolism, Metabolomics, NMR and MRI Methods, Systems Biology.

Research Interest: Clinical Nephrology, Metabolic Syndrome, Hypertension, Inflammation

Ricardo Alaxandre de Azevedo, PhD, Graduated in Biological Science by the University ‘Santa Cecília’- Santos (Brazil) in 2002, MSc degree in Biotechology by the University of São Paulo (Brazil) in 2010, and Ph.D. in Toxinology by the Butantan Institute (Brazil) in 2014. Presently, Postdoctoral Fellow, Department Immunology, Laboratory of Tumor Immunology, University São Paulo, July 2014-current. Also occupy position of  Research Scientist, and Coordinator of Biological Assays Division at ALCHEMY, RESEARCH AND DEVELOPMENT, February-current.  I have experience and scientific production in the area of Apoptosis and cell cycle signaling, peptides and peptidases, molecular biology and cancer genetics, cells immunology, with emphasis on biochemotherapy and immunotherapy of cancer, focusing murine melanoma and human tumors. 

Research Interest: Embryonic Stem Cells, Pluripotency, Induced Pluripotent Cells, Differentiation, Endoderm, Beta Cell, Diabetes, Obesity, Adipose Tissue, Brown Fat, Endothelium, Oxidative Stress, Nitric Oxide, Peroxynitrite, Superoxide, Nanosensors.

Research Interest: Genes Involved in Cell Cycle Regulation, Differentiation, Apoptosis and Senescence Such as the Retinoblastoma (RB) Family. He has Evaluated the Role of Retinoblastoma Genes in the Regulation of Cell Proliferation, Differentiation and Apoptosis in
Cancer and Normal Stem Cells. In Detail, his Group has Analyzed the Biology of Neural Stem Cells and Mesenchymal Stem Cells. These Studies Prompted the Attention Also on Chromatin
Remodeling Factors that Interact with RB Family Members and Play a Key Role in the Life of StemCells.

Research Interest: Neurology

Research Interest: Cancer Stem Cell, such as Surface Marker, Biology, and Mechanism.

Research Interest: Cancer Stem Cell, Anticancer Agent, Metastasis, Cell Survival, Cell Migration, Apoptosis, Molecular and Cell Signaling, Transcription Factors, Xenograft Model, Stem Cell Based Therapy.

Research Interest: In his Consulting Experience, Devyn Led a Wide Range of Projects, Across Multiple Therapeutic Areas and a Host of Technology Platforms, Including Basic R&D Tools, Regenerative Medicine, Gene Therapy and Macromolecules/Biologic Products.

Research Interest: As Is Clear From The Biography, Shigetaka Asano Accomplisheddistinguished Performance In Research Based On Medical Needs By Full Of Enthusiasm With State-Of-The-Art New Technology, Such As 1. Verification Of Existence Of Rabbit Neutrophil Cell Membrane Knack+-Atpase, 2. Discovery Of Laterarity Of Mouse Intestinal Mucous Membrane Proteins, 3. Finding Of Human Tumor Cell Mediated By Granulocyte Colony-Stimulating Factor (G-CSF; Bioactive Substance To Stimulate Differentiation, Proliferation And Functional Activity Of Neutrophil), 4. Analysis Of Human G-CSF Activity, 5. Succeeding In Incubation Of Human Tumor Infiltrating T Lymphocyte Colony, 6. Discovery Of Allogenicimmunosuppression Of Placenta Decidual Cells, 7. Differentiation Induction Of Mesenchymalstem Cell, 8. Cloning Of G-Csfcdna And Development Of Recombinant Human Native G-CSF (Lenograstim) As The 1st Generation Biomedicine, 9. Constitution Of International Clinical Guideline For Transplantation Of Bone-Marrow And Cord Blood, And Construction Of Public Bank Of Bone-Marrow And Cord Blood, 10. Non-Clinical Study Of Human Granulocyte Colony-Stimulating Factor (GM-CSF; Bioactive Substance To Stimulate Differentiation, Proliferation And Functional Activity Of Macrophage Besides Neutrophil)Immunogene Therapy And Execution Of The Phase Iia Clinical Study, 11. Non-Clinical Study Of Utilizing Maxizyme For Immunogene Therapy Of Myeloid Leukemia Cell, 12. Acquisition And Molecular Analysis Of Leukemia Stem Cell Like Property By Stochastic Adhesion Of In Vitro Human Myelogenous Leukemic Cell Line Cell And Stromal Cell, 13. Pathological Analysis Of Mesenchymalstem Cell(Parental Cell Of Range Of Cell Consist Ofstroma) Differentiation And Proliferation In Translin(Substance Found As Molecule To Bind Fusion Gene Of Lymphatic Leukemia) Knockout Mouse. 

Research Interest: Fate Decisions of Embryonic Stem Cell, Induced Pluripotent Stem Cell (ESC/Ips): Pluripotency and Direct Lineage Specification to the Three Germ Layers.

Research Interest: Focuses on Aging-Related Diseases and Stem Cell Transplantation. 

Research Interest: Bone Marrow Transplantation, Immunology, Autoimmunity, Thymus and Bone Marrow Derived-Mesenchymal Stem Cells. His Cutting-Edge Technology for Bone Marrow Cell Harvesting and Intra-Bone Marrow-Bone Marrow Transplantation has Led to Significant Research Into Allogeneic Stem Cell Transplantation. 

Research Interest:

Two Major Projects are Currently Underway in the Laboratory.
A Cell Reprogramming Technique Has Been Used to Convert Heterogeneous Malignant Breast Cancer Cells into Induced Pluripotent Stem Cells Using Sox2/Oct4/Nanog Proteins. Dr. Wu’s Laboratory is Clarifying these Induced Pluripotent Stem Cells for their Differentiation Potential and Oncogenic Properties, and Try to Develop a Novel Cell Converting Therapy for Malignant Breast Cancer Treatment.
Metastasis, the Spread of Cancer Cells from the Primary Tumor To Distant Organs, Is The Most Dreadful Development Of Breast Cancer, As Well As Other Neoplastic Diseases. Although Metastasis Contributes To Over 90% Of Human Cancer Mortality, The Molecular Mechanism Of This Process Remains Largely Unknown. Dr. Wu’s Laboratory Is In The Process Of Identifying Molecular Signatures Involved In Breast Cancer Metastasis Using Integrative Genetic, Epigenetic And Proteomic Approach, As Well As Animal Models And Clinical Specimens. 

Research Interest: During those Years She Extended her Initial Research Interests on Endothelial Progenitor Cell (EPC) Biology and their Potential use in Regenerative Medicine.